Sep 8, 2022

Microdose Announces Algernon Pharmaceuticals as Wonderland's Headline Sponsor

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Miami, Florida--(Newsfile Corp. - September 8, 2022) - Microdose Psychedelic Insights, the leading guide to the business of psychedelics, is thrilled to announce Algernon Pharmaceuticals (CSE: AGN) (FSE: AGW0) (OTCQB: AGNPF) ("Algernon") as the official Headline Sponsor for Wonderland, the world-leading event in the psychedelic medicine industry. The highly anticipated gathering is coming back to Miami from November 3-5th, 2022, at the Mana Wynwood Convention Centre in Miami's Arts and Entertainment District. The Algernon's CEO, Christopher J. Moreau, will deliver two keynote addresses:

Business Session Keynote November 4th, 1:00 pm EST

Science Session Keynote November 5th 2:00 pm EST

Wonderland is the world's largest ever business gathering in the psychedelic medicine sector. It provides an opportunity to Discover the world of psychedelic medicine along with some of the leading founders, investors, therapists, practitioners, researchers, thought leaders, innovators, and media from around the globe.

"We are delighted to welcome our friends at Algernon Pharmaceuticals as a sponsor of the conference and to have them involved with our programs. Wonderland Miami is a one-of-a-kind event, and we are very pleased to continue our collaboration with Algernon Pharmaceuticals as an official headline sponsor."
~ Patrick Moher, President of Microdose Psychedelic Insights

Algernon has established a clinical research program for the treatment of stroke focused on AP-188 ("N,N-Dimethyltryptamine or DMT"), a known psychedelic compound that is part of the tryptamine family (other drugs in the tryptamine family include psilocybin and psilocin). Algernon plans to be the first company globally to investigate DMT as a possible treatment for stroke and is planning to begin a Phase 1 clinical trial beginning in Q4, 2022.

The Company's decision to investigate DMT and move it into human trials for stroke is based on multiple independent, positive preclinical studies demonstrating that DMT helps promote neurogenesis as well as structural and functional neural plasticity. These are key factors involved in the brain's ability to form and reorganize synaptic connections, which are needed for healing following a brain injury.

The Company has now completed its intravenous formulation ("IVF") that will be used in the Phase 1 DMT study. The formulation was developed by the Centre for Human Drug Research ("CHDR") and its affiliated pharmacy at the Leiden University Medical Center in the Netherlands. The Company has applied for ethics and clinical trial approval and is expecting to have a response shortly.

"We are delighted to be the headline sponsor for the Wonderland 2022 event and have the opportunity to build a greater awareness of Algernon and our DMT stroke research program within the many different facets of the psychedelic medicine world."

~ Christopher J. Moreau, CEO, Algernon Pharmaceuticals

Phase 1 DMT Stroke Study Summary

The purpose of Algernon's planned study is to identify the safety, tolerability, and pharmacokinetics of DMT when administered as an intravenous bolus followed by prolonged infusion. The first part of the study will use a single-escalating dose design while the second part will test the effects of repeated administrations of the highest safe dose. There will be up to 60 healthy volunteers enrolled across the two parts of the study which will include both psychedelic experienced and psychedelic naïve patients.

About N,N-Dimethyltryptamine, or DMT, is a hallucinogenic tryptamine drug producing effects similar to those of other psychedelics like LSD, ketamine, psilocybin and psilocin. DMT occurs naturally in many plant species and animals including humans and has been used in religious ceremonies as a traditional spiritual medicine by indigenous people in the Amazonian basin. DMT can also be synthesised in a laboratory.

Algernon has filed provisional patents for new salt forms of DMT, in addition to formulation, dosage and method of use claims for ischemic stroke. The Company has also filed claims for combination therapy of DMT and stroke rehabilitation including Constraint Induced Movement Therapy.

About Microdose Psychedelic Insights

Microdose Psychedelic Insights aims to unlock the potential of psychedelic medicine through Industry events, market intelligence, original, evidence-based content, strategy, and community. We enable and empower society at large to make better, more mindful decisions about psychedelics and their intersection with healthcare, medicine, and personal growth. We work with the industry's most influential stakeholders, some of the world's best-known brands, and an unrivalled network of scientists, researchers, analysts, innovators, investors, and advisors.

About Wonderland

Wonderland offers the psychedelic medicine industry a unique in-person convergence of business, science, music, and emerging technologies. Fostering creative and professional growth, Wonderland: Miami is the premier destination for the psychedelic medicine industry. The event is a thought-leadership platform and an opportunity to connect with influential leaders in science, policy, and business. It acts as a launching pad for innovative content connected to the psychedelic medicine space, with musical showcases and documentary screenings, providing compelling entertainment and collaboration opportunities for attendees. Wonderland is all about real-life events featuring high-quality programming in some of the world's most exciting locations and breath-taking venues.

About Algernon Pharmaceuticals Inc.

Algernon is a drug re-purposing company that investigates safe, already approved drugs for new disease applications, moving them efficiently and safely into new human trials, developing new formulations and seeking new regulatory approvals in global markets. Algernon specifically investigates compounds that have never been approved in the U.S. or Europe to avoid off label prescription writing.

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